Description

Palmitoyl Coenzyme A, [Palmitoyl-1-14C] is a radiolabeled derivative of palmitoyl-CoA, a key intermediate in fatty acid metabolism. This compound is specifically labeled with carbon-14 at the 1-position of the palmitoyl moiety, making it an indispensable tool for tracing and quantifying metabolic pathways in biochemical research. It is primarily utilized by researchers and scientists in pharmaceutical development, metabolic disease studies, and lipid biochemistry to investigate β-oxidation, lipid synthesis, and enzyme kinetics with high precision.

Application

• Enzyme Activity Assays: Used as a substrate for studying the kinetics and inhibition of enzymes like carnitine palmitoyltransferase (CPT), acyl-CoA synthetases, and other acyltransferase enzymes.
• Metabolic Pathway Tracing: Essential for radioisotopic tracing studies to elucidate the β-oxidation pathway of fatty acids within mitochondria and peroxisomes.
• Lipid Metabolism Research: Employed in cell-based and in vitro assays to investigate disorders of fatty acid metabolism, such as those related to diabetes, obesity, and cardiovascular diseases.
• Drug Discovery & Development: Serves as a critical reagent in high-throughput screening (HTS) campaigns to identify novel therapeutics targeting metabolic enzymes.
• Biochemical Mechanism Studies: Facilitates detailed studies on protein acylation, membrane biogenesis, and the regulation of metabolic flux.
• Diagnostic Kit Development: Used in the development and calibration of diagnostic assays for measuring specific enzyme deficiencies.

Basic Information

Product Name	Palmitoyl Coenzyme A, [Palmitoyl-1-14C]
CAS No.	72089-31-7
Molecular Formula	C37H66N7O17P3S * (Labeled)
Molecular Weight	~1005.9 g/mol (unlabeled)
Synonyms	1-[14C]Palmitoyl-CoA; [1-14C]Palmitoyl-Coenzyme A; Palmitoyl-1-14C-Coenzyme A; Hexadecanoyl-CoA (1-14C); Coenzyme A, S-hexadecanoate-1-14C; Palmitoyl-CoA-1-14C; Radiolabeled Palmitoyl CoA; Fatty Acyl-CoA (C16:0, 1-14C)
EINECS	Contact for details

Quality Control

Every batch of Palmitoyl Coenzyme A, [Palmitoyl-1-14C] is manufactured and tested under stringent conditions to ensure the highest standards of radiochemical purity and biological activity. Our quality assurance protocol includes verification of specific activity, radiochemical purity by HPLC, and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, specific activity (mCi/mmol), and analytical methods is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store frozen at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated at -70°C. Avoid repeated freeze-thaw cycles. Handle in accordance with all applicable radiation safety regulations and guidelines.

Specification

Item	Specification
Appearance	White to off-white solid or frozen solution
Identification (HPLC, MS)	Conforms to structure
Assay (Radiochemical Purity)	≥ 95% by Radio-HPLC
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (if supplied as solution)	Specified aqueous buffer (e.g., ammonium acetate)
Concentration	As specified per batch (µCi/mL or nmol/µL)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.