Description

Clofibric Acid Acyl-B-D-Glucuronide is a key metabolite of the lipid-regulating agent clofibrate, formed via glucuronidation. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in bioanalytical method development, metabolite identification, and regulatory safety testing.

Application

• Metabolite Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of clofibrate metabolites in biological matrices.
• Pharmacokinetic Studies: Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand the metabolic pathway and clearance of clofibrate.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC-MS/MS or LC-MS methods for drug and metabolite monitoring in plasma, urine, or serum.
• Toxicology and Safety Assessment: Employed in studies to assess the potential toxicity and safety profile of drug metabolites.
• Doping Control Analysis: Potential use as a reference compound in sports anti-doping laboratories for detecting prohibited substances and their metabolites.
• Enzyme Activity Assays: Can be used in vitro to study the activity and kinetics of UDP-glucuronosyltransferase (UGT) enzymes.

Basic Information

Product Name	Clofibric Acid Acyl-B-D-Glucuronide
CAS No.	72072-47-0
Molecular Formula	C19H24O9
Molecular Weight	396.39 g/mol
Synonyms	Clofibric Acid Glucuronide; Clofibrate Glucuronide; 1-O-(4-Chlorophenoxyisobutyryl)-β-D-glucopyranuronic Acid; 2-(4-Chlorophenoxy)-2-methylpropanoic acid β-D-glucopyranosiduronic acid; Acyl Glucuronide of Clofibric Acid; CPIB Glucuronide; Clofibrate Metabolite
EINECS	Contact for details

Quality Control

Our Clofibric Acid Acyl-B-D-Glucuronide is manufactured under strict quality control protocols suitable for research and analytical applications. Each batch is characterized using advanced spectroscopic and chromatographic techniques to ensure identity, purity, and stability. We provide comprehensive Certificates of Analysis (COA) with detailed results for all critical parameters, including assay purity and impurity profiles. Our quality system supports compliance with relevant standards for high-purity reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.