Description

3-Methyladenosine is a modified nucleoside derivative of adenosine, featuring a methyl group at the N3 position of the adenine base. This specific structural modification makes it a valuable biochemical tool and a key intermediate in the synthesis of more complex nucleoside analogs. It is primarily utilized in pharmaceutical research, life science studies, and as a building block for novel therapeutic agents. Researchers and manufacturers in the fields of medicinal chemistry, biochemistry, and oligonucleotide synthesis rely on this high-purity compound for its consistent quality and reliable performance.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate methylation pathways and RNA metabolism.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop new therapeutic agents targeting various diseases.
• Life Science Reagent: Acts as a standard or reference compound in analytical methods such as HPLC and LC-MS for nucleoside quantification.
• Oligonucleotide Synthesis: Utilized as a modified monomer for incorporating specific functionalities into synthetic DNA or RNA strands.
• Enzyme Mechanism Probes: Helps in elucidating the mechanisms of methyltransferase and other nucleic acid-modifying enzymes.

Basic Information

Product Name	3-Methyladenosine
CAS No.	72055-62-0
Molecular Formula	C11H15N5O4
Molecular Weight	281.27 g/mol
Synonyms	3-Methyladenosine; N3-Methyladenosine; 3-Methyl-9-β-D-ribofuranosyl-9H-purin-6-amine; 9-β-D-Ribofuranosyl-3-methyladenine; 3-Methyl-A; 3-MeA; 3-Methyladenosine (3-MeA); 3-Methyl-adenosine
EINECS	Contact for details

Quality Control

Our 3-Methyladenosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to meet the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We adhere to industry best practices and can support compliance needs for various research and cGMP-grade applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.