Description

Adenosine 5'-Diphosphate 2',3'-Acyclic Dialcohol, Sodium Salt is a chemically modified nucleotide analog of adenosine diphosphate (ADP). This compound is significant as a stable, non-hydrolyzable analog of ADP, making it a valuable tool for biochemical research and enzymatic studies where the hydrolysis of the terminal phosphate must be prevented. It is primarily needed by researchers in pharmaceutical development, enzymology, and molecular biology for investigating ATP/ADP-dependent processes, such as kinase and synthase activities.

Application

• Enzymology Research: Used as a substrate analog to study the mechanism and kinetics of ATPases, kinases, and other ADP-binding enzymes without hydrolysis.
• Pharmaceutical Screening: Serves as a critical reagent in high-throughput screening assays to identify potential inhibitors or modulators of ADP-dependent targets.
• Biochemical Assay Development: Employed in the development of robust, non-radioactive assay systems for monitoring enzymatic activity.
• Structural Biology: Utilized in X-ray crystallography and NMR studies to elucidate the structure of enzyme active sites bound to an ADP-mimic.
• Metabolic Pathway Analysis: Acts as a probe to dissect complex metabolic pathways involving adenylate energy transfer.
• Diagnostic Reagent Manufacturing: Incorporated as a key component in the formulation of diagnostic kits for clinical chemistry analyzers.

Basic Information

Product Name	Adenosine 5'-Diphosphate 2',3'-Acyclic Dialcohol, Sodium Salt
CAS No.	71997-42-7
Molecular Formula	C10H13N5O9P2Nax (x=2-3)
Molecular Weight	Approx. 489.1 (Free acid, anhydrous basis)
Synonyms	ADP-2',3'-Dialcohol; 2',3'-Dideoxyadenosine-5'-diphosphate; Adenosine 5'-(trihydrogen diphosphate), 2',3'-dideoxy-, sodium salt; ADP Dialcohol; Non-hydrolyzable ADP analog; β,γ-Methylene-ADP analog (structural analog); 5'-ADP-2',3'-seco-derivative
EINECS	Contact for details

Quality Control

Our production of Adenosine 5'-Diphosphate 2',3'-Acyclic Dialcohol, Sodium Salt adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and assess purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your research and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (UV)	≥ 90% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.