Description

Cathepsin S CAS NO 71965-46-3 is a cysteine protease enzyme belonging to the papain superfamily, playing a critical role in antigen presentation and immune response modulation. Its specific inhibition is a key target for therapeutic research in autoimmune diseases, inflammatory disorders, and certain cancers. This high-purity biochemical is essential for researchers and developers in the pharmaceutical, biotechnology, and life science sectors, enabling advanced drug discovery and diagnostic assay development.

Application

• Drug Discovery & Development: Primary target for developing inhibitors to treat autoimmune conditions like rheumatoid arthritis, lupus, and multiple sclerosis.
• Biochemical Research: Used as a tool enzyme to study MHC class II-mediated antigen processing and immune system regulation.
• In Vitro Diagnostic (IVD) Kits: Component in assay kits for measuring protease activity in research and clinical samples.
• Oncology Research: Investigation of its role in tumor progression, angiogenesis, and metastasis.
• Inflammatory Disease Models: Utilized in cellular and animal models to understand and validate pathways in chronic inflammatory diseases.
• Enzyme Characterization Studies: Substrate for kinetic studies, inhibitor screening, and mechanistic enzymology.

Basic Information

Product Name	Cathepsin S
CAS No.	71965-46-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Cath S; CATS; CTSS; EC 3.4.22.27; Major excreted protein; MEP; Cathepsin S (human); Cathepsin S (bovine); Cathepsin S (recombinant)
EINECS	Contact for details

Quality Control

Our Cathepsin S is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and high biological activity. Each lot is characterized for purity, specific activity, and absence of contaminating proteases. Certificates of Analysis (COA) detailing assay results, including activity (units/mg) and purity profile, are provided and available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in a non-frost-free freezer. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to prevent condensation. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Activity)	Conforms
Specific Activity	> 1000 units/mg protein
Purity (SDS-PAGE)	> 95%
Protein Content (Bradford)	Contact for details
Endotoxin Level (LAL)	< 1.0 EU/μg
Residual Moisture (KF)	< 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.