Description

Guanosine 5'-o-(2-Thiodiphosphate) Trilithium Salt is a high-purity, chemically modified nucleotide analog where a sulfur atom replaces one of the non-bridging oxygen atoms in the diphosphate moiety. This compound is a critical biochemical tool, serving as a hydrolysis-resistant analog of GDP and GTP, making it invaluable for studying G-protein coupled receptor (GPCR) signaling pathways and nucleotide-dependent enzymatic processes. It is primarily utilized by researchers and manufacturers in pharmaceutical R&D, biochemical assay development, and enzymology.

Application

• Biochemical Research: Used as a non-hydrolyzable GTP analog to study the activation and regulation of G-proteins and GTPases.
• Enzyme Mechanism Studies: Employed to investigate the kinetics and binding of enzymes that utilize GDP/GTP as substrates or allosteric effectors.
• GPCR Signaling Assays: Essential component in cell-based and cell-free assays to probe signal transduction pathways involving GPCRs.
• Pharmaceutical Screening: Utilized in high-throughput screening (HTS) platforms to identify potential drug candidates that modulate nucleotide-binding proteins.
• Diagnostic Reagent Manufacturing: Serves as a key raw material in the production of specialized diagnostic kits for cellular signaling analysis.
• Structural Biology: Used in X-ray crystallography and NMR studies to determine the structure of protein-nucleotide complexes.

Basic Information

Product Name	Guanosine 5'-o-(2-Thiodiphosphate) Trilithium Salt
CAS No.	71783-24-9
Molecular Formula	C10H12Li3N5O12P2S
Molecular Weight	519.07 g/mol
Synonyms	GDPβS trilithium salt; Guanosine 5'-[β-thio]diphosphate trilithium salt; 2'-Deoxyguanosine-5'-O-[1-thiodiphosphate] trilithium salt; GDNPS trilithium salt; Guanylyl 5'-(β-thio)diphosphate trilithium salt; GTPγS analog; Non-hydrolyzable GDP analog; CAS 71783-24-9
EINECS	Contact for details

Quality Control

Our Guanosine 5'-o-(2-Thiodiphosphate) Trilithium Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as purity (HPLC), identity (NMR, MS), and moisture content. We adhere to ISO 9001 quality management principles, and our production environment is designed to prevent cross-contamination.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.