Description

Z-Abu-Osu CAS NO 71447-81-9 is a specialized amino acid derivative and activated ester, primarily utilized as a key building block in peptide synthesis and bioconjugation chemistry. Its core value lies in enabling the efficient and selective formation of amide bonds, a fundamental reaction for constructing complex biomolecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing novel peptide-based therapeutics, diagnostic probes, and advanced materials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester derivative of Fmoc-protected aminobutyric acid, it is a crucial reagent for the controlled incorporation of the Abu (2-aminobutyric acid) residue into peptide chains.
• Solution-Phase Peptide Coupling: Facilitates amide bond formation in solution-based strategies for synthesizing peptides and peptidomimetics.
• Bioconjugation and Labeling: Used to attach peptides, tags, or payloads to proteins, antibodies, or other biomolecules for creating targeted drug conjugates or diagnostic tools.
• Research & Development: Serves as a critical building block in medicinal chemistry for structure-activity relationship (SAR) studies and the development of novel bioactive compounds.
• Custom Peptide Production: Employed by CROs and CDMOs for the reliable and scalable synthesis of custom peptides for clients.
• Material Science: Can be used to functionalize surfaces or polymers with peptide motifs to create bioactive materials.

Basic Information

Product Name	Z-Abu-Osu
CAS No.	71447-81-9
Molecular Formula	C20H20N2O6
Molecular Weight	384.39 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-aminobutyric acid N-hydroxysuccinimide ester; Fmoc-2-Abu-OH N-succinimidyl ester; Fmoc-Abu-OSu; Nα-Fmoc-L-2-aminobutyric acid succinimidyl ester; Z-2-Aminobutyric acid N-hydroxysuccinimide ester; N-Fmoc-2-aminobutyric acid succinimidyl ester; Fmoc-Abu-OSu ester; N-[(9-Fluorenylmethoxy)carbonyl]-2-aminobutyric acid N-succinimidyl ester
EINECS	Contact for details

Quality Control

Every batch of Z-Abu-Osu is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes results from HPLC, NMR, and MS analyses. Our production adheres to cGMP guidelines where applicable, ensuring reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.