Description

18,19-Dihydrorifampicin is a key semi-synthetic derivative of the potent antibiotic rifampicin, offering a distinct chemical profile for advanced research and development. This compound is valued for its role as a critical intermediate and reference standard in the synthesis and analytical study of novel rifamycin-class antibiotics. It is primarily utilized by pharmaceutical R&D teams, analytical laboratories, and fine chemical manufacturers focused on anti-infective drug discovery and quality control.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel rifamycin derivatives and next-generation antibiotics.
• Analytical Reference Standard: Used in High-Performance Liquid Chromatography (HPLC) and other analytical methods for the identification, assay, and impurity profiling of rifampicin and related substances.
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) and mechanism of action of rifamycin antibiotics against bacterial RNA polymerase.
• Impurity Standard: Serves as a certified reference material (CRM) for quantifying and qualifying specified impurities in rifampicin Active Pharmaceutical Ingredient (API) according to pharmacopeial standards (e.g., USP, EP).
• Metabolite Studies: Used in research to understand the metabolic pathways and degradation products of rifampicin.

Basic Information

Product Name	18,19-Dihydrorifampicin
CAS No.	71397-49-4
Molecular Formula	C43H60N4O13
Molecular Weight	841.0 g/mol
Synonyms	18,19-Dihydro Rifampicin; 18,19-Dihydro Rifampin; 18,19-Dihydro Rifamycin AMP; 23-(Acetyloxy)-12,21,27-trihydroxy-2,4,16,20,22,24,26-heptamethyl-1,15-dioxo-1,2,15,16,23,24,25,26-octahydro-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-8-yl methyl carbonate; Rifampicin Impurity D (EP); Rifampin Related Compound D (USP); 18,19-Dihydro Rifampicin Q
EINECS	Contact for details

Quality Control

Our 18,19-Dihydrorifampicin is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-purity standards suitable for research and reference use. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to meet specific pharmacopeial (USP/EP) impurity identification requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	Reddish-brown to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.