Description

1-(Trimethylsilyl)-1-Propyn-3-Yl Tosylate is a specialized organosilicon building block and electrophilic reagent used in advanced organic synthesis. This compound is valued for its ability to introduce the trimethylsilyl-protected propynyl group, a versatile handle for further functionalization, under mild conditions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing alkyne functionalities for click chemistry or further coupling reactions.
• Agrochemical Synthesis: Used in the production of novel pesticides and herbicides where the propynyl moiety is a critical structural component.
• Material Science: Serves as a precursor in the development of silicon-containing polymers, dendrimers, and other advanced organic materials.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various metal-catalyzed cross-coupling reactions to form new carbon-carbon bonds.
• Natural Product Synthesis: Employed in the total synthesis of complex natural products requiring the installation of a protected acetylene unit.
• Ligand and Catalyst Development: Useful for synthesizing novel ligands and organometallic catalysts with tailored properties.

Basic Information

Product Name	1-(Trimethylsilyl)-1-Propyn-3-Yl Tosylate
CAS No.	71321-16-9
Molecular Formula	C13H18O3SSi
Molecular Weight	282.43 g/mol
Synonyms	3-[(Trimethylsilyl)ethynyl]propyl 4-methylbenzenesulfonate; Propargyl Tosylate, Trimethylsilyl-; Tosyloxypropyl Trimethylsilylacetylene; 1-Propyn-3-yl Tosylate, 1-Trimethylsilyl-; (3-Tosyloxyprop-1-yn-1-yl)trimethylsilane; 4-Methylbenzenesulfonic Acid 3-[(Trimethylsilyl)ethynyl]propyl Ester
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-1-Propyn-3-Yl Tosylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.