Description

3-Iodopyridine-Adenine Dinucleotide Phosphate is a chemically modified dinucleotide cofactor analog, specifically engineered for advanced biochemical research and development. This compound is critical for studying enzyme mechanisms, particularly those involving NAD(P)-dependent dehydrogenases, where it acts as an affinity label or a mechanistic probe. It is an essential reagent for pharmaceutical researchers, enzymologists, and diagnostic developers working on metabolic pathways, inhibitor design, and novel assay development.

Application

• Enzyme Mechanism Studies: Used as an active-site directed affinity labeling agent for NAD(P)-dependent enzymes to elucidate catalytic mechanisms.
• Pharmaceutical Research: Serves as a key intermediate or probe in the development of enzyme inhibitors targeting metabolic disorders and cancers.
• Diagnostic Assay Development: Employed in the design and validation of high-sensitivity biochemical assays for clinical diagnostics.
• Bioconjugation & Probe Synthesis: Acts as a versatile building block for synthesizing fluorescent or biotinylated probes for protein labeling and detection.
• Structural Biology: Aids in X-ray crystallography and NMR studies by facilitating the co-crystallization of enzyme-cofactor complexes.
• Metabolic Pathway Analysis: Utilized as a tool to investigate specific steps in cellular redox reactions and energy metabolism.

Basic Information

Product Name	3-Iodopyridine-Adenine Dinucleotide Phosphate
CAS No.	71187-05-8
Molecular Formula	C21H26IN6O14P2
Molecular Weight	823.22 g/mol
Synonyms	3-Iodo-PADP; 3-Iodopyridine Adenine Dinucleotide Phosphate; Iodo-NADP; 3-I-NADP; NADP analog, 3-iodopyridine; Adenosine 5'-(trihydrogen diphosphate), P'→5'-ester with 3-(iodo-5-phospho-D-ribofuranosyl)pyridine; 3-Iodopyridinium adenine dinucleotide phosphate
EINECS	Contact for details

Quality Control

Our 3-Iodopyridine-Adenine Dinucleotide Phosphate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant guidelines for research-grade biochemicals to support your critical R&D and diagnostic development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and storage under inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.