Description

Dl-Threo-2-Methylisocitrate CAS NO 71183-66-9 is a specialized organic acid derivative of isocitrate, serving as a key chiral intermediate and biochemical research tool. Its value lies in its role as a precursor or inhibitor in the study of metabolic pathways, particularly those involving the tricarboxylic acid (TCA) cycle and glyoxylate shunt. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors who require high-purity, structurally-defined molecules for synthesis, process development, and enzymatic studies.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies of aconitase and isocitrate lyase to investigate metabolic regulation.
• Pharmaceutical Intermediate: Serves as a chiral building block in the synthesis of potential therapeutic agents targeting metabolic diseases.
• Agrochemical Development: Employed in the research and synthesis of novel compounds with herbicidal or fungicidal activity by interfering with plant-specific metabolic cycles.
• Metabolomics & Diagnostics: Acts as a reference standard in analytical methods (LC-MS, GC-MS) for quantifying metabolic flux in biological samples.
• Enzyme Mechanism Studies: Utilized to probe the stereospecificity and catalytic mechanisms of enzymes within the citrate-isocitrate pathway.
• Fine Chemical Synthesis: A valuable starting material for the preparation of more complex, stereochemically-defined molecules for various industrial applications.

Basic Information

Product Name	Dl-Threo-2-Methylisocitrate
CAS No.	71183-66-9
Molecular Formula	C7H10O7
Molecular Weight	206.15 g/mol
Synonyms	DL-threo-2-Methylisocitric acid; (±)-threo-2-Methylisocitric acid; 2-Methylisocitrate; 1-Hydroxy-1,2,3-propanetricarboxylic acid, 2-methyl-; 2-Methyl-1-hydroxy-1,2,3-propanetricarboxylic acid; three-2-Methylisocitric acid (racemic); Methylisocitric acid
EINECS	Contact for details

Quality Control

Our Dl-Threo-2-Methylisocitrate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis, to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	DL-threo isomer ≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.