Description

Leukotriene B4 CAS NO 71160-24-2 is a potent pro-inflammatory lipid mediator belonging to the eicosanoid family, derived from arachidonic acid metabolism. It plays a critical role in the innate immune response, primarily by mediating neutrophil chemotaxis, adhesion, and degranulation. This makes it an essential biochemical tool and reference standard for researchers in immunology, pharmacology, and inflammatory disease research, particularly for studying asthma, arthritis, psoriasis, and other inflammatory conditions.

Application

• Biomedical Research: Used as a critical reference standard and agonist in studies of inflammation, immune cell signaling, and leukocyte biology.
• Drug Discovery & Development: Serves as a key ligand for screening and validating potential inhibitors of the LTB4 pathway (e.g., BLT receptor antagonists) for anti-inflammatory therapeutics.
• In Vitro Diagnostics (IVD): Employed as a calibrator and control in ELISA and other immunoassay kits designed to quantify LTB4 levels in biological samples.
• Cell Biology Studies: Applied to induce and model neutrophil and eosinophil migration, activation, and oxidative burst in experimental settings.
• Signal Transduction Research: Utilized to investigate G-protein-coupled receptor (GPCR) pathways, specifically the BLT1 and BLT2 receptors.
• Academic & Pharmaceutical R&D: A fundamental reagent for understanding the molecular mechanisms of chronic inflammatory and autoimmune diseases.

Basic Information

Product Name	Leukotriene B4
CAS No.	71160-24-2
Molecular Formula	C₂₀H₃₂O₄
Molecular Weight	336.47 g/mol
Synonyms	LTB4; (5S,12R)-Dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic Acid; 5(S),12(R)-Dihydroxy-6,8,10,14-eicosatetraenoic Acid; Leukotriene B-4; (5S,12R)-Dihydroxyicosa-6Z,8E,10E,14Z-tetraenoic Acid; Inflammation Mediator B4
EINECS	Contact for details

Quality Control

Our Leukotriene B4 is produced and handled under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to rigorous analytical standards, utilizing techniques such as HPLC and MS for verification, ensuring the product meets the exacting requirements of pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. Store away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.