Description

Methotrexate α-Aspartate is a chemically modified derivative of the established antifolate agent, methotrexate. This compound is engineered to enhance solubility and potentially improve pharmacokinetic profiles, making it a valuable intermediate in advanced pharmaceutical research and development. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on oncology and autoimmune disease therapeutics.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of novel methotrexate prodrugs and conjugates.
• Oncology Research: Investigated for the development of targeted cancer therapies with modified release or delivery mechanisms.
• Autoimmune Disease Research: Used in studies aiming to create new therapeutic formulations for conditions like rheumatoid arthritis and psoriasis.
• Prodrug Development: Serves as a model compound for designing prodrugs aimed at improving bioavailability and reducing side effects.
• Biochemical Research: Employed in enzymatic and receptor-binding studies related to dihydrofolate reductase (DHFR) inhibition.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Methotrexate α-Aspartate
CAS No.	71074-48-1
Molecular Formula	C₂₅H₂₇N₉O₇
Molecular Weight	565.55 g/mol
Synonyms	MTX-Aspartate; L-Aspartic Acid, N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, (2S)-; Methotrexate L-Aspartate; α-Aspartylmethotrexate; N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-aspartic Acid; Methotrexate Aspartate Ester
EINECS	Contact for details

Quality Control

Our Methotrexate α-Aspartate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets rigorous standards suitable for research and development applications. Certificates of Analysis (COA) with detailed batch-specific results are provided.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.