Description

(R)-1,1-Diphenyl-1-fluoro-2-aminopropane is a chiral, fluorinated amine building block of significant interest in advanced organic synthesis. This compound matters because its unique structure, featuring a stereogenic center, a fluorine atom, and a primary amine group, makes it a versatile precursor for creating complex, biologically active molecules. Pharmaceutical research and development laboratories need it for the synthesis of potential drug candidates, particularly in areas requiring chiral discrimination and the metabolic stability conferred by fluorine substitution.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and metabolic disorder therapeutics.
• Asymmetric Catalyst Ligand Precursor: Used to develop novel chiral ligands for asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Agrochemical Synthesis: Serves as a building block for creating advanced, fluorinated agrochemicals with improved efficacy and environmental profile.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials where fluorine incorporation modifies physical properties.
• Medicinal Chemistry Probe: Utilized in structure-activity relationship (SAR) studies to investigate the impact of fluorine and chirality on biological activity.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in chiral analysis.

Basic Information

Product Name	(R)-1,1-Diphenyl-1-fluoro-2-aminopropane
CAS No.	71057-03-9
Molecular Formula	C15H16FN
Molecular Weight	229.30 g/mol
Synonyms	(R)-α-Fluoro-α,α-diphenylmethylamine; (R)-1-Amino-1-fluoro-2,2-diphenylethane; (R)-1-Fluoro-2-amino-1,1-diphenylpropane; (R)-1,1-Diphenyl-2-aminopropyl fluoride; (R)-F-Diphenylmethylamine; (R)-FDPA; (R)-Fenfluramine intermediate (chiral); (R)-1-Fluoro-1,1-diphenyl-2-propanamine
EINECS	Contact for details

Quality Control

Our (R)-1,1-Diphenyl-1-fluoro-2-aminopropane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) determination and standard purity assays, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.