Description

1-(2'-Tetrahydrothienyl)-5-Fluorouracil-1'-Oxide is a specialized fluorinated pyrimidine derivative, a key intermediate in advanced pharmaceutical synthesis. This compound is valued for its role in the development of novel chemotherapeutic agents and other bioactive molecules. It is primarily required by research institutions and pharmaceutical manufacturers engaged in oncology drug discovery and the synthesis of modified nucleoside analogs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of experimental anti-cancer and antiviral prodrugs.
• Oncology Research: Used in biochemical and pharmacological studies targeting thymidylate synthase and DNA synthesis pathways.
• Nucleoside Analog Development: Serves as a precursor for creating modified fluorouracil derivatives with enhanced therapeutic profiles.
• Academic & Contract Research: Employed in university and CRO laboratories for medicinal chemistry projects and mechanism-of-action studies.
• Process Chemistry: Utilized in scale-up and optimization studies for the manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-(2'-Tetrahydrothienyl)-5-Fluorouracil-1'-Oxide
CAS No.	70758-92-8
Molecular Formula	C9H9FN2O3S
Molecular Weight	244.24 g/mol
Synonyms	FT-207; Tegafur; Ftorafur; 5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione 1-Oxide; 1-(2-Tetrahydrofuryl)-5-fluorouracil 1-Oxide; NSC 148958; FTORAFURUM; 1-(Tetrahydro-2-furanyl)-5-fluorouracil 1-Oxide
EINECS	Contact for details

Quality Control

Our 1-(2'-Tetrahydrothienyl)-5-Fluorouracil-1'-Oxide is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC, NMR, and MS to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.