Description

n-Succinimidyl Butyrate is a versatile active ester reagent widely used in bioconjugation and peptide synthesis. Its primary value lies in its ability to efficiently couple carboxylic acids to primary amines under mild conditions, forming stable amide bonds. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require reliable cross-linking agents for modifying biomolecules, creating drug conjugates, or developing diagnostic reagents.

Application

• Bioconjugation Agent: For the covalent attachment of proteins, antibodies, peptides, or other biomolecules to labels, surfaces, or drug molecules.
• Peptide Synthesis: Acts as a coupling reagent in solid-phase and solution-phase peptide synthesis to form peptide bonds.
• Polymer Functionalization: Used to introduce reactive succinimidyl ester groups onto polymers for subsequent conjugation with amine-containing compounds.
• Surface Modification: Employed to create amine-reactive surfaces on chips, beads, or plates for biosensor and microarray development.
• Antibody-Drug Conjugate (ADC) Development: A key reagent in the synthesis of linkers for connecting cytotoxic drugs to monoclonal antibodies.
• Diagnostic Reagent Production: For labeling proteins or haptens with enzymes, fluorophores, or other detection moieties in immunoassays.

Basic Information

Product Name	n-Succinimidyl Butyrate
CAS No.	70741-39-8
Molecular Formula	C8H11NO4
Molecular Weight	185.18 g/mol
Synonyms	Butyric Acid N-Hydroxysuccinimide Ester; N-Hydroxysuccinimidyl Butyrate; NHS-Butyrate; Succinimidyl Butanoate; N-(Butanoyloxy)succinimide; Butyryloxy Succinimide; 1-[(Butanoyloxy)-2,5-pyrrolidinedione]; Butanoic Acid 2,5-Dioxo-1-pyrrolidinyl Ester
EINECS	Contact for details

Quality Control

Our n-Succinimidyl Butyrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and production applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.