Description

Z-Arg-Amc Hcl is a specialized peptide derivative and fluorogenic substrate widely used in biochemical research and pharmaceutical development. This compound serves as a critical tool for the study of protease activity, particularly for enzymes like trypsin and related serine proteases. It is essential for researchers and manufacturers in the fields of pharmaceutical R&D, diagnostic assay development, and enzymology, where precise measurement of enzymatic kinetics is required.

Application

• Protease Activity Assays: Primary substrate for fluorometrically monitoring the activity of trypsin and trypsin-like serine proteases.
• Drug Discovery Screening: Used in high-throughput screening (HTS) platforms to identify and characterize novel protease inhibitors.
• Biochemical Research: A key reagent for studying enzyme kinetics, specificity, and inhibition mechanisms in academic and industrial laboratories.
• Diagnostic Kit Development: Incorporated into diagnostic kits for the detection and quantification of specific protease biomarkers.
• Quality Control in Biologics: Employed to assess the presence and activity of residual proteases in biopharmaceutical manufacturing processes.
• Cell Biology Studies: Used to investigate protease-mediated signaling pathways and cellular processes.

Basic Information

Product Name	Z-Arg-Amc Hcl
CAS No.	70375-22-3
Molecular Formula	C20H30N6O4 • HCl
Molecular Weight	446.96 g/mol
Synonyms	Z-Arg-AMC hydrochloride; Benzyloxycarbonyl-L-arginine 7-amido-4-methylcoumarin hydrochloride; Z-Arg-7-amido-4-methylcoumarin hydrochloride; Cbz-Arg-AMC HCl; Nα-Carbobenzoxy-L-arginine 7-amido-4-methylcoumarin hydrochloride; Z-L-Arg-AMC • HCl; Z-Arg-AMC • HCl; Substrate for trypsin (fluorogenic)
EINECS	Contact for details

Quality Control

Our Z-Arg-Amc Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.