Description

Brimonidine Tartrate CAS NO 70359-46-5 is a selective α-2 adrenergic receptor agonist, formulated as the tartrate salt for enhanced stability and bioavailability. This compound is a critical active pharmaceutical ingredient (API) valued for its potent vasoconstrictive and intraocular pressure-lowering effects. It is primarily required by pharmaceutical manufacturers and research institutions developing ophthalmic solutions for the treatment of glaucoma and ocular hypertension.

Application

• Ophthalmic Drug Formulations: Primary API in prescription eye drops for managing open-angle glaucoma and ocular hypertension.
• Pharmaceutical Intermediates: Serves as a key synthetic intermediate in the production of more complex adrenergic compounds.
• Research & Development: Used in preclinical and clinical studies investigating α-2 adrenergic pathways.
• Reference Standards: High-purity grade is utilized as a chromatographic reference standard in analytical laboratories for quality control.
• Cosmeceutical Applications: Investigated for use in topical formulations aimed at reducing facial erythema and rosacea symptoms.

Basic Information

Product Name	Brimonidine Tartrate
CAS No.	70359-46-5
Molecular Formula	C11H10BrN5 • C4H6O6
Molecular Weight	442.24 g/mol (for the tartrate salt)
Synonyms	5-Bromo-6-(2-imidazolidinylideneamino)quinoxaline L-tartrate; UK-14,304-18; Brimonidine L-tartrate; ALPHAGAN® P (Brand Name API); Brimonidine (base); UK 14,304; Brimonidine tartrate salt; 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine (2R,3R)-2,3-dihydroxybutanedioate
EINECS	Contact for details

Quality Control

Our Brimonidine Tartrate is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure compliance with relevant pharmacopeial standards (such as USP/EP) for identity, purity, and potency. A comprehensive Certificate of Analysis (COA) detailing all test results, including assay, related substances, residual solvents, and heavy metals, is provided with each batch to guarantee supply chain transparency and regulatory readiness.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.