Description

Z-Lys-Pna CAS NO 70144-71-7 is a protected lysine derivative, specifically the benzyloxycarbonyl (Z or Cbz) protected form of lysine para-nitroanilide. This compound serves as a critical synthetic intermediate and biochemical tool, valued for its role in peptide synthesis and enzyme substrate studies. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic peptides and investigating protease activity.

Application

• Peptide Synthesis Intermediate: Used as a key building block in solid-phase and solution-phase peptide synthesis, particularly for introducing lysine residues with orthogonal protection.
• Protease/Enzyme Substrate: Acts as a chromogenic substrate for the study and assay of various proteolytic enzymes, such as trypsin and plasmin, due to the para-nitroaniline (pNA) leaving group.
• Biochemical Research: Employed in academic and industrial research laboratories to investigate enzyme kinetics, inhibition, and mechanism of action.
• Pharmaceutical Development: Utilized in the research and development stages of peptide-based drug candidates and diagnostic agents.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical chemistry.

Basic Information

Product Name	Z-Lys-Pna
CAS No.	70144-71-7
Molecular Formula	C₂₀H₂₄N₄O₅
Molecular Weight	400.43 g/mol
Synonyms	Nα-CBZ-L-Lysine p-nitroanilide; CBZ-L-Lysine pNA; Z-L-Lysine 4-nitroanilide; Nα-Benzyloxycarbonyl-L-lysine 4-nitroanilide; N-Carbobenzoxy-L-lysine p-nitroanilide; Cbz-Lys-pNA; Benzyl N-[5-amino-1-[(4-nitrophenyl)amino]-1-oxopentan-2-yl]carbamate; L-Lysine, N2-[(phenylmethoxy)carbonyl]-, 4-nitroanilide
EINECS	Contact for details

Quality Control

Our Z-Lys-Pna is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.