Description

Salicylic Acid n-Hydroxysuccinimide Ester is a versatile and highly reactive chemical intermediate, primarily used for the derivatization and labeling of biomolecules. Its core value lies in its ability to efficiently introduce a salicylate moiety onto primary amines, enabling applications in fluorescence detection, cross-linking, and targeted drug delivery systems. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic reagent industries who require reliable, high-purity building blocks for advanced synthesis.

Application

• Bioconjugation Reagent: For the covalent attachment of salicylic acid derivatives to proteins, peptides, and antibodies for fluorescence labeling and detection.
• Cross-linking Agent: Used in the preparation of immunoconjugates and antibody-drug conjugates (ADCs) for targeted therapeutic applications.
• Fluorescent Probe Synthesis: Acts as a key precursor in the development of salicylate-based fluorescent sensors and probes for biochemical assays.
• Polymer Modification: Enables the functionalization of amine-containing polymers to introduce specific chemical or biological activity.
• Diagnostic Reagent Manufacturing: Employed in the synthesis of components for enzyme-linked immunosorbent assays (ELISA) and other diagnostic kits.
• Research & Development: A critical tool in academic and industrial R&D for studying protein interactions, cell signaling, and drug targeting mechanisms.

Basic Information

Product Name	Salicylic Acid n-Hydroxysuccinimide Ester
CAS No.	70120-40-0
Molecular Formula	C11H9NO5
Molecular Weight	235.19 g/mol
Synonyms	2-Hydroxybenzoic Acid N-Hydroxysuccinimide Ester; Salicyloyloxy N-Hydroxysuccinimide; NHS-Salicylate; N-Hydroxysuccinimidyl Salicylate; Salicylic Acid NHS Ester; N-Succinimidyl Salicylate; 2-[(2,5-Dioxopyrrolidin-1-yl)oxycarbonyl]phenol; Salicylate-OSu
EINECS	Contact for details

Quality Control

Our Salicylic Acid n-Hydroxysuccinimide Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Products undergo rigorous analytical testing, including HPLC for assay and purity determination, to meet the stringent requirements of research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.