Description

Merrifield Resin CAS NO 70024-51-0 is a cross-linked chloromethylated polystyrene polymer, widely recognized as the foundational solid support for solid-phase peptide synthesis (SPPS). Its primary value lies in providing a stable, insoluble matrix for the stepwise assembly of peptide chains, enabling high-efficiency purification and automation. This product is essential for research institutions, pharmaceutical developers, and biotechnology companies engaged in peptide drug discovery, combinatorial chemistry, and the production of complex organic molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): The primary and most significant application, serving as the anchor for Fmoc- or Boc-protected amino acids during automated or manual peptide assembly.
• Combinatorial Library Generation: Used to create vast libraries of peptides or small organic molecules for high-throughput screening in drug discovery campaigns.
• Oligonucleotide Synthesis: Can be adapted as a solid support for the synthesis of DNA or RNA fragments in some methodologies.
• Organic Synthesis Scaffold: Employed as a polymeric reagent or scavenger in various organic transformations, facilitating purification.
• Affinity Chromatography Media: Functionalized resin used as a base matrix for preparing custom affinity columns to purify specific proteins or biomolecules.
• Catalyst Support: Serves as an inert carrier for immobilizing transition metal catalysts or organocatalysts for heterogeneous catalysis.

Basic Information

Product Name	Merrifield Resin
CAS No.	70024-51-0
Molecular Formula	(C9H9Cl)n (Representative monomer unit)
Molecular Weight	~152.62 g/mol (monomer) - Polymer MW varies with cross-linking and loading.
Synonyms	Chloromethylated Polystyrene Resin; Polystyrene-chloromethyl Resin; Merrifield's Peptide Resin; 2% DVB Cross-linked Chloromethyl Polystyrene; SPPS Resin; Wang Resin Precursor; 4-Chloromethyl Polystyrene; Crosslinked Chloromethylstyrene Polymer
EINECS	Contact for details

Quality Control

Our Merrifield Resin is manufactured under strict quality protocols to ensure batch-to-batch consistency critical for synthetic reproducibility. Each lot is characterized for key parameters including chlorine content (loading capacity), particle size distribution, and swelling properties in common solvents. A Certificate of Analysis (COA) detailing these specifications is provided with every shipment, supporting compliance in GMP and research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C). The resin is stable under inert atmosphere but should be kept away from strong bases and nucleophiles to prevent degradation of the chloromethyl functional group.

Specification

Item	Specification
Appearance	White to off-white beads
Loading Capacity	0.5 - 1.5 mmol Cl/g (Typical, various grades available)
Cross-linking (DVB)	1%, 2% (Standard)
Particle Size	100-200 mesh, 200-400 mesh (Standard ranges)
Swelling Volume	Reported (DCM, DMF, THF)
Identification (IR)	Conforms
Moisture Content (KF)	< 5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.