Description

Anecortave Acetate is a synthetic angiostatic corticosteroid specifically designed for ophthalmic applications. This compound matters for its targeted mechanism of action, which effectively inhibits the formation of new, leaky blood vessels without the typical glucocorticoid side effects. It is primarily needed by pharmaceutical manufacturers and research institutions developing treatments for serious eye diseases. Its unique profile makes it a critical active pharmaceutical ingredient for addressing conditions driven by abnormal angiogenesis.

Application

• Ophthalmic Pharmaceutical Formulations: Primary use as the active ingredient in injectable suspensions for treating neovascular (wet) age-related macular degeneration (AMD).
• Angiogenesis Inhibition Research: A key reference compound in preclinical and clinical studies investigating anti-angiogenic therapies for various ocular and non-ocular conditions.
• Posterior Juxtascleral Administration: Specifically formulated for delivery via a unique posterior juxtascleral depot method to achieve sustained local therapeutic effect.
• Development of Novel Drug Delivery Systems: Used in R&D for advanced ophthalmic implants, microparticles, or other sustained-release technologies.
• Comparative Efficacy Studies: Employed in research to benchmark the performance of newer anti-VEGF and combination therapies for retinal diseases.

Basic Information

Product Name	Anecortave Acetate
CAS No.	7753-60-8
Molecular Formula	C₂₄H₃₂O₅
Molecular Weight	400.51 g/mol
Synonyms	9α,11β-Dichloro-6α-fluoro-16α,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate; 4,9(11)-Pregnadien-17α,21-diol-3,20-dione, 9,11-dichloro-6-fluoro-21-(acetyloxy)-, (6α,17α)-; AL-3789; RETAANE; Ancotave; Ancoratave Acetate
EINECS	Contact for details

Quality Control

Our Anecortave Acetate is manufactured under strict quality management systems suitable for pharmaceutical ingredient supply. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay, related substances, residual solvents, and microbiological quality are provided and can be tailored to meet specific pharmacopeial or client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details
Microbiological Quality	Meets standard bioburden limits for non-sterile API

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.