Description

Guanosine 3':5'-Cyclic Monophosphate CAS NO 7665-99-8 is a crucial nucleotide derivative that serves as a key secondary messenger in cellular signal transduction pathways. Its primary commercial value lies in its essential role for biochemical research, pharmaceutical development, and diagnostic applications. This high-purity biochemical is primarily needed by biotechnology companies, academic and pharmaceutical R&D laboratories, and manufacturers of diagnostic kits and research reagents.

Application

• Biochemical Research: Fundamental studies of cyclic nucleotide signaling, protein kinase activation, and cellular physiology.
• Pharmaceutical Development: Used as a reference standard, intermediate, or active component in drug discovery programs targeting G-protein-coupled receptors and related pathways.
• Diagnostic Manufacturing: A critical component in the production of enzyme immunoassay (EIA) and radioimmunoassay (RIA) kits for clinical and research use.
• Cell Culture & Physiology: Applied in cell-based assays to study the effects of cGMP on ion channels, apoptosis, and other cellular functions.
• Enzyme Substrate: Serves as a specific substrate for phosphodiesterases (PDEs) in enzyme activity and inhibition studies.
• Signal Transduction Kits: Used in commercial kits designed to measure intracellular cGMP levels as a readout for various receptor activities.

Basic Information

Product Name	Guanosine 3':5'-Cyclic Monophosphate
CAS No.	7665-99-8
Molecular Formula	C10H12N5O7P
Molecular Weight	345.21 g/mol
Synonyms	Cyclic GMP; cGMP; Guanosine cyclic 3',5'-(hydrogen phosphate); 3',5'-Cyclic GMP; Guanosine 3',5'-monophosphate; 3',5'-cGMP; Guanosine 3',5'-cyclic phosphate; 9-β-D-Ribofuranosylguanine 3',5'-cyclic phosphate
EINECS	231-622-4

Quality Control

Our Guanosine 3':5'-Cyclic Monophosphate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and diagnostic applications. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed HPLC purity data, identity confirmation (IR, NMR), and impurity profiles. Our quality commitment aligns with the standards expected for biochemical reagents in pharmaceutical and diagnostic manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or refrigerated (2-8°C) as specified. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
pH (1% Solution)	2.0 - 4.0
Optical Rotation	-47° to -53° (c=1 in water)
UV Absorption (A250/A260)	0.80 - 0.90
Solubility	Freely soluble in water; slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.