Description

Dolichol is a long-chain, polyprenol-type isoprenoid alcohol that serves as a critical lipid carrier molecule in essential biochemical pathways. Its primary commercial value lies in its role as a precursor in the biosynthesis of N-linked glycoproteins and glycosylphosphatidylinositol (GPI) anchors, processes fundamental to cellular function and protein modification. This makes high-purity Dolichol CAS NO 7541-50-6 a vital raw material for research institutions and manufacturers in the pharmaceutical, biotechnology, and nutraceutical industries.

Application

• Biochemical Research: Essential substrate for studying protein glycosylation, GPI-anchor biosynthesis, and dolichol phosphate cycle mechanisms.
• Pharmaceutical Intermediates: Used as a key starting material or intermediate in the synthesis of complex glycoconjugates and investigational therapeutic agents.
• Cell Culture & Biotechnology: Added to specialized cell culture media to optimize the production of recombinant glycoproteins and monoclonal antibodies.
• Enzyme Studies: Serves as a cofactor or substrate for enzymes like dolichol kinase and oligosaccharyltransferase in in vitro assays.
• Nutraceutical Research: Investigated for its potential role in membrane stability and cellular health, supporting product development in advanced supplements.
• Diagnostic Reagent Manufacturing: Incorporated into diagnostic kits and reagents used for studying metabolic disorders related to glycosylation.

Basic Information

Product Name	Dolichol
CAS No.	7541-50-6
Molecular Formula	Typically C80-105H134-180O (Variable chain length)
Molecular Weight	~1100-1500 g/mol (Average)
Synonyms	Polyprenol; all-trans-Polyprenol; α-Saturated Polyprenol; Dolichols; 2,3-Dihydro-2,3-polyprenol; (all-E)-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75,79-Eicosamethyloctaconta-2,6,10,14,18,22,26,30,34,38,42,46,50,54,58,62,66,70,74,78-octaene-1-ol (for a specific isomer); Dolichol (pig liver)
EINECS	231-420-0

Quality Control

Our Dolichol is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chain length distribution analysis, to ensure it meets the stringent requirements for research and manufacturing applications. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white waxy solid
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95% (Total Dolichol)
Chain Length (HPLC)	Predominantly C80-C105 (Custom distributions available)
Loss on Drying	≤ 1.0 %
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.