Description

Boc-Glu(Obzl)-Onp is a protected amino acid derivative widely used as a key building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring high-purity intermediates to construct complex peptides with specific side-chain protection. It is particularly valuable in the pharmaceutical and biotechnology sectors for the development of novel therapeutic peptides, APIs, and research biochemicals. The product is supplied under stringent quality control to ensure batch-to-batch consistency and optimal performance in sensitive synthetic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): A crucial intermediate for the controlled incorporation of glutamic acid with orthogonal side-chain protection.
• Solution-Phase Peptide Synthesis: Used in the synthesis of complex peptides and small proteins where precise coupling is required.
• Pharmaceutical Intermediate: Serves as a building block in the research and production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation & Labeling: The active ester (Onp) group facilitates efficient conjugation to other molecules, amines, or surfaces.
• Chemical Biology Research: Employed in the synthesis of peptide probes, enzyme substrates, and inhibitors for biochemical studies.
• Custom Peptide Service: A fundamental reagent for CROs and CDMOs offering bespoke peptide manufacturing services.

Basic Information

Product Name	Boc-Glu(Obzl)-Onp
CAS No.	7536-59-6
Molecular Formula	C23H26N2O7
Molecular Weight	442.46 g/mol
Synonyms	N-α-Boc-L-glutamic acid 5-benzyl ester p-nitrophenyl ester; Boc-L-Glu(OBzl)-ONp; Boc-Glu(OBzl)-ONp; tert-Butyloxycarbonyl-L-glutamic acid γ-benzyl ester p-nitrophenyl ester; (S)-2-((tert-Butoxycarbonyl)amino)-5-(benzyloxy)-5-oxopentanoic acid 4-nitrophenyl ester; Boc-Glu-OBzl-ONp; Boc-L-Glutamic acid 5-benzyl ester 4-nitrophenyl ester; N-Boc-L-glutamic acid γ-benzyl ester p-nitrophenyl ester
EINECS	Contact for details

Quality Control

Our Boc-Glu(Obzl)-Onp is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure it meets the high standards required for peptide synthesis. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to GMP principles where applicable, and our quality system is designed to support regulatory filings for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.