Description

H-Pro-Pna Hbr is a high-purity, non-natural amino acid derivative widely utilized in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of complex peptides and peptidomimetics, enabling the exploration of novel therapeutic agents. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality intermediates for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptide Chemistry: Used as a protected proline analog for constructing specialized peptide sequences with enhanced stability or biological activity.
• Protease Inhibitor Development: Serves as a core scaffold in the design and development of enzyme inhibitors targeting various disease pathways.
• Bioconjugation: Employed in the preparation of peptide-based conjugates for diagnostic and targeted drug delivery applications.
• Chemical Biology Research: Utilized as a tool compound to study protein-protein interactions and enzyme mechanisms.
• Fine Chemical Synthesis: Acts as a versatile intermediate in multi-step organic syntheses for complex molecular architectures.

Basic Information

Product Name	H-Pro-Pna Hbr
CAS No.	7369-91-7
Molecular Formula	C₁₁H₁₃N₃O₃ • HBr
Molecular Weight	316.15 g/mol
Synonyms	H-Pro-pNA HBr; L-Prolyl-p-nitroanilide hydrobromide; Pro-pNA HBr; Prolyl-4-nitroanilide HBr; 1-[(2S)-Pyrrolidine-2-carbonyl]-4-nitroaniline hydrobromide; Pyrrolidine-2-carboxylic acid (4-nitro-phenyl)-amide hydrobromide; Protease substrate derivative; Chromogenic protease substrate.
EINECS	Contact for details

Quality Control

Our H-Pro-Pna Hbr is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.