Description

Guanosine 5'-Monophosphomorpholidate 4-Morpholine-N,N'-Dicyclohexylcarboxamidine Salt is a high-purity, activated nucleotide derivative used as a critical reagent in oligonucleotide synthesis. This compound matters for its role in facilitating the efficient and specific formation of phosphodiester bonds, enabling the production of high-quality RNA and DNA sequences. It is essential for researchers and manufacturers in the fields of pharmaceutical development, molecular biology, and diagnostic assay production, where reliable and scalable nucleic acid synthesis is paramount.

Application

• Solid-Phase Oligonucleotide Synthesis: A key reagent for the automated synthesis of DNA and RNA strands on solid supports.
• Pharmaceutical Intermediates: Used in the production of active pharmaceutical ingredients (APIs) for antisense oligonucleotides and siRNA therapeutics.
• Research & Development: Critical for academic and industrial R&D labs studying gene function, developing probes, and creating synthetic genes.
• Diagnostic Reagent Manufacturing: Employed in the synthesis of primers, probes, and other nucleic acid components for PCR, qPCR, and sequencing-based diagnostics.
• Bioconjugation: Facilitates the site-specific labeling of oligonucleotides with fluorophores, biotin, or other functional groups.

Basic Information

Product Name	Guanosine 5'-Monophosphomorpholidate 4-Morpholine-N,N'-Dicyclohexylcarboxamidine Salt
CAS No.	7361-07-1
Molecular Formula	C₂₆H₄₃N₈O₈P
Molecular Weight	626.65 g/mol
Synonyms	GMP Morpholidate, Morpholidate Salt; Guanosine 5'-Monophosphomorpholidate Salt; Guanosine 5'-(4-Morpholinephosphoramidate) Morpholidate Salt; P1-(Guanosine-5'-yl) P2-(4-morpholinyl) phosphoramidomorpholidate; GMP-Morpholidate; 4-Morpholine-N,N'-dicyclohexylcarboxamidine guanosine 5'-monophosphomorpholidate; Activated Guanosine Monophosphate
EINECS	Contact for details

Quality Control

Our Guanosine 5'-Monophosphomorpholidate Salt is produced under stringent conditions to ensure batch-to-batch consistency and high chemical purity suitable for sensitive synthetic applications. All materials are subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMF, DMSO; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.