Description

Colchicine, n-Methyl- is a methylated derivative of the well-known alkaloid colchicine. This compound is a critical intermediate and reference standard in pharmaceutical research and development, particularly for the synthesis of novel colchicine analogs. It is primarily utilized by research institutions and pharmaceutical companies engaged in anti-inflammatory and anti-cancer drug discovery programs, as well as in biochemical studies investigating tubulin dynamics.

Application

• Pharmaceutical Intermediate: Serves as a key building block for the synthesis of novel colchicine derivatives and prodrugs with potential therapeutic applications.
• Biochemical Research: Used as a reference standard and tool compound in studies of microtubule polymerization and depolymerization dynamics.
• Anti-inflammatory Agent Development: Investigated for the development of new treatments for gout and other inflammatory conditions.
• Oncology Research: Employed in cancer research to study anti-mitotic agents and develop novel chemotherapeutic candidates.
• Analytical Reference Standard: Used in HPLC, LC-MS, and other analytical methods for method development, validation, and quality control of related substances.

Basic Information

Product Name	Colchicine, n-Methyl-
CAS No.	7336-40-5
Molecular Formula	C23H27NO6
Molecular Weight	413.46 g/mol
Synonyms	N-Methylcolchicine; Colchicine N-Methyl Ether; 3-[(7S)-1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]methyl]-N,N-dimethylpropanamide; Demecolcine Impurity; N-Methylcolchiceinamide; N-Methyl-N-deacetylcolchicine; Colchiceine Amide N-Methyl Ether
EINECS	Contact for details

Quality Control

Our Colchicine, n-Methyl- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR, MS). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing purity, impurities, and other critical parameters to ensure compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.