Description

2-Bromoacetyl Coenzyme A is a critical biochemical reagent, specifically a reactive acyl-CoA analog, widely used as a key intermediate in enzymatic and metabolic research. Its primary value lies in its ability to act as a mechanism-based inhibitor and an affinity labeling agent for enzymes that utilize acetyl-CoA as a substrate, enabling detailed study of active sites and catalytic mechanisms. This compound is essential for researchers and manufacturers in pharmaceutical development, biochemistry, and enzymology, particularly for investigating acetyltransferase and synthase activities.

Application

• Enzymology Research: As a mechanism-based inhibitor for studying acetyl-CoA utilizing enzymes like choline acetyltransferase and histone acetyltransferases.
• Active Site Labeling: Used as an affinity probe to covalently label and identify the active sites of target enzymes for structural and functional analysis.
• Metabolic Pathway Studies: A tool compound for probing metabolic pathways involving acyl-CoA intermediates, such as fatty acid synthesis and the citric acid cycle.
• Pharmaceutical Development: Serves as a building block or inhibitor scaffold in the discovery of novel therapeutics targeting metabolic disorders or epigenetic regulation.
• Bioconjugation: Utilized for the site-specific modification of proteins or peptides via its reactive bromoacetyl group.
• Biochemical Assay Development: A key reagent in developing high-throughput screening assays for enzyme activity and inhibitor discovery.

Basic Information

Product Name	2-Bromoacetyl Coenzyme A
CAS No.	7303-38-0
Molecular Formula	C₂₃H₃₈BrN₇O₁₇P₃S
Molecular Weight	922.46 g/mol
Synonyms	2-Bromoacetyl-CoA; Bromoacetyl CoA; S-(2-Bromoacetyl)coenzyme A; Coenzyme A, S-(2-bromoacetyl)-; Acetyl-CoA, 2-bromo-; 2-Bromoacetylcoenzyme A; Bromoacetyl-Coenzyme A; S-(Bromoacetyl) CoA
EINECS	Contact for details

Quality Control

Our 2-Bromoacetyl Coenzyme A is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Biological Activity	Tested in standard enzymatic inhibition assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.