Description

1-Oleoyl-2-Stearoyl-Sn-Glycero-3-Phosphocholine is a high-purity, synthetic phospholipid that serves as a critical component in the formulation of advanced lipid-based delivery systems. Its defined fatty acid composition provides superior consistency and performance compared to natural lecithin mixtures, making it essential for research and development requiring precise membrane modeling. This compound is primarily utilized by pharmaceutical, biotechnology, and advanced cosmetic industries for applications such as liposome preparation, drug delivery, and membrane biophysics studies.

Application

• Liposome & Lipid Nanoparticle (LNP) Formulation: A key structural lipid for creating stable, uniform vesicles for drug and gene delivery systems, including mRNA vaccines.
• Membrane Biophysics Research: Used as a standard or model phospholipid to study membrane fluidity, phase behavior, and protein-lipid interactions in artificial bilayers.
• Cosmetic & Dermal Delivery: Incorporated into high-end cosmetic formulations like nanosomes and transfersomes to enhance the penetration and stability of active ingredients.
• Diagnostic Reagents: Serves as a component in diagnostic kits and assays that require specific phospholipid substrates or membrane environments.
• Cell Culture & Cryopreservation: Used as a supplement in specialized cell culture media and as a cryoprotectant agent for stabilizing cell membranes.
• Biomimetic Coatings: Applied in the development of sensor chips and medical device coatings that require biocompatible, cell-membrane-like surfaces.

Basic Information

Product Name	1-Oleoyl-2-Stearoyl-Sn-Glycero-3-Phosphocholine
CAS No.	7276-38-2
Molecular Formula	C46H90NO8P
Molecular Weight	816.18 g/mol
Synonyms	OSPC; 18:1-18:0 PC; 1-Oleoyl-2-stearoyl-phosphatidylcholine; (2R)-2-[(1-Oxooctadec-9-en-1-yl)oxy]-3-(stearoyloxy)propyl 2-(trimethylammonio)ethyl phosphate; Phosphatidylcholine (18:1/18:0); POPC (Note: Often confused, but POPC is 16:0/18:1); DSPC (Note: Often confused, but DSPC is 18:0/18:0); L-α-Phosphatidylcholine, 1-oleoyl-2-stearoyl-
EINECS	Contact for details

Quality Control

Our 1-Oleoyl-2-Stearoyl-Sn-Glycero-3-Phosphocholine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and GMP-grade applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, fatty acid composition, and critical impurities. We adhere to relevant industry guidelines for phospholipid characterization to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive) and easily oxidized. For short-term use, vials may be stored at 2-8°C. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or waxy solid
Identification (HPLC/MS)	Complies
Assay (HPLC)	≥ 98.0%
Fatty Acid Composition (GC)	Oleic Acid (C18:1): 45-55% Stearic Acid (C18:0): 45-55%
Lyso-Phosphatidylcholine	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%
Peroxide Value	≤ 3.0 meq/kg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.