Description

5-Mercapto-2'-Deoxyuridine is a modified nucleoside analog of deoxyuridine, where a thiol group replaces the methyl group at the 5-position. This compound matters as a critical biochemical tool and precursor in the synthesis of oligonucleotides and probes for molecular biology and diagnostic applications. It is primarily needed by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers for applications in nucleic acid research, antiviral studies, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a key intermediate in the study of nucleic acid metabolism, enzyme mechanisms (e.g., thymidylate synthase), and DNA repair pathways.
• Antiviral Drug Development: Serves as a precursor or analog in the synthesis of potential nucleoside-based antiviral agents targeting viral polymerases.
• Molecular Probe Synthesis: Incorporated into oligonucleotides to create thiol-labeled probes for hybridization assays, biosensors, and diagnostic applications.
• Radiopharmaceuticals: Can be used as a starting material for the synthesis of radiolabeled compounds (e.g., with S-35) for tracer studies and medical imaging research.
• Cross-linking Studies: The thiol group enables its use in creating cross-linked DNA structures or conjugates with other biomolecules for structural biology studies.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for pharmaceutical development.

Basic Information

Product Name	5-Mercapto-2'-Deoxyuridine
CAS No.	7085-54-3
Molecular Formula	C9H12N2O5S
Molecular Weight	260.27 g/mol
Synonyms	5-Thio-2'-deoxyuridine; 2'-Deoxy-5-thiouridine; 5-SH-dUrd; d5SU; 5-Mercaptodeoxyuridine; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-sulfanylpyrimidine-2,4(1H,3H)-dione; 5-Thiouridine deoxy
EINECS	Contact for details

Quality Control

Our 5-Mercapto-2'-Deoxyuridine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent internal quality standards to meet the demands of pharmaceutical and life science research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep the container tightly sealed to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.