Description

Aminopterinsodium CAS NO 7007-85-4 is the sodium salt form of the potent folic acid antagonist, aminopterin. This compound is a critical biochemical tool for research in cell biology and oncology, primarily used to inhibit dihydrofolate reductase (DHFR). It is essential for scientists and pharmaceutical developers working in targeted cancer therapy research, enzyme inhibition studies, and the investigation of cell proliferation mechanisms.

Application

• Biochemical Research: As a selective inhibitor of dihydrofolate reductase (DHFR) for studying folate metabolism and nucleotide biosynthesis pathways.
• Oncology & Cancer Research: A key reference compound for developing and testing novel antifolate chemotherapeutic agents and studying drug resistance mechanisms.
• Cell Culture & Selection: Used in molecular biology for the selection of transfected cells in media lacking specific nutrients (e.g., HAT medium selection protocols).
• Enzyme Kinetics Studies: Employed to determine enzyme inhibition constants and study the catalytic mechanism of DHFR and related enzymes.
• Pharmacological Screening: Serves as a positive control or benchmark in high-throughput screening assays for new anticancer drug candidates.
• Academic & Institutional Research: Fundamental tool in university and institutional labs for graduate-level research in biochemistry, pharmacology, and molecular genetics.

Basic Information

Product Name	Aminopterinsodium
CAS No.	7007-85-4
Molecular Formula	C19H18N8NaO5
Molecular Weight	461.39 g/mol
Synonyms	4-Aminofolic Acid Sodium Salt; Aminopterin Sodium; Sodium Aminopterin; 4-Aminopteroylglutamate Sodium Salt; NSC-739; L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, sodium salt (1:1); 4-Amino-PGA Sodium Salt; Aminopterin Na
EINECS	Contact for details

Quality Control

Every batch of our Aminopterinsodium is manufactured and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. We provide comprehensive analytical documentation, including a detailed Certificate of Analysis (COA) with results from HPLC, NMR, and mass spectrometry. Our quality system is designed to meet the rigorous standards expected by the global research and pharmaceutical development community.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.