Description

Dl-Normetanephrine CAS NO 709-52-4 is a synthetic catecholamine metabolite and a key intermediate in the study of adrenergic pathways and neurotransmitter metabolism. This compound is of significant value for research and development in neurochemistry and clinical diagnostics. It is primarily required by pharmaceutical R&D laboratories, diagnostic kit manufacturers, and academic institutions for use as a reference standard and a critical biochemical reagent.

Application

• Pharmaceutical Reference Standard: Used for the calibration and validation of analytical methods in drug metabolism and pharmacokinetics (DMPK) studies.
• Diagnostic Reagent Manufacturing: Serves as a key component in the production of enzyme-linked immunosorbent assay (ELISA) kits and other in vitro diagnostic (IVD) tests for catecholamine analysis.
• Biochemical Research: Employed in neuroscience and endocrinology research to investigate the synthesis, release, and degradation pathways of norepinephrine and epinephrine.
• Metabolite Analysis: Acts as a critical standard in liquid chromatography-mass spectrometry (LC-MS) and high-performance liquid chromatography (HPLC) for quantifying normetanephrine levels in biological samples.
• Quality Control (QC) Testing: Utilized by pharmaceutical companies for impurity profiling and method development for related substances in active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Dl-Normetanephrine
CAS No.	709-52-4
Molecular Formula	C9H13NO3
Molecular Weight	183.20 g/mol
Synonyms	DL-Normetanephrine; (±)-Normetanephrine; 3,4-Dihydroxyphenylglycol methyl ether; 4-[2-Amino-1-hydroxyethyl]-2-methoxyphenol; 3-O-Methylnoradrenaline; Normetanephrine Hydrochloride (salt form); DL-3-Methoxy-4-hydroxyphenylethanolamine; NSC 406119
EINECS	211-915-9

Quality Control

Our Dl-Normetanephrine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and diagnostic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability and to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.