Description

Rhynchophylline is a prominent indole alkaloid derived from the *Uncaria* genus of plants, known for its unique tetracyclic oxindole structure. This compound is of significant commercial and research interest due to its well-documented biological activity, particularly as a calcium channel blocker and NMDA receptor antagonist. It is primarily sought by the pharmaceutical, nutraceutical, and research sectors for applications in neurological and cardiovascular health, as well as for use as a high-purity reference standard.

Application

• Pharmaceutical Intermediate: Serves as a key starting material or active ingredient in the research and development of neuroprotective and cardiovascular drugs.
• Dietary Supplement Formulation: Incorporated into nutraceutical products targeting cognitive support, blood pressure regulation, and overall neurological wellness.
• Reference Standard: Used in analytical laboratories for the quality control and standardization of herbal extracts, particularly those containing *Uncaria rhynchophylla* (Cat's Claw).
• Biochemical Research: Employed in *in vitro* and *in vivo* studies to investigate mechanisms related to neuroprotection, vasodilation, and anti-inflammatory pathways.
• Cosmeceutical Ingredients: Explored for potential use in topical formulations aimed at improving skin health due to its antioxidant properties.

Basic Information

Product Name	Rhynchophylline
CAS No.	76-66-4
Molecular Formula	C22H28N2O4
Molecular Weight	384.47 g/mol
Synonyms	Mitrinermine; Rhynchophyllin; (7R,16R,19E)-7,16-Dihydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester; 16-Carbomethoxy-17-methoxy-2-oxocorynoxan; Corynoxan-16-carboxylic acid, 17-methoxy-2-oxo-, methyl ester, (7β,16β,19E)-; UNC-1A; Geissoschizine methyl ether, oxindole derivative
EINECS	200-976-1

Quality Control

Our Rhynchophylline is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and tests for residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.