Description

Veratridine is a potent, naturally occurring steroidal alkaloid derived from plants of the *Liliaceae* family, such as *Schoenocaulon officinale* and *Veratrum album*. It is a highly selective and well-characterized pharmacological tool compound that functions as a persistent activator of voltage-gated sodium (NaV) channels. This unique mechanism of action makes it indispensable for advanced life science research and drug discovery. Key industries and applications include neuroscience research, ion channel studies, pharmaceutical development, and as a reference standard in analytical chemistry.

Application

• Neuroscience & Ion Channel Research: Primary tool for studying the gating mechanisms, kinetics, and pharmacology of voltage-gated sodium channels in neuronal and cardiac tissues.
• Pharmacological Studies: Used to induce and model prolonged sodium channel activation in cellular assays to investigate channel blockers, modulators, and neurotoxicity.
• Drug Discovery & Screening: Serves as a positive control or challenge agent in high-throughput screening (HTS) platforms to identify novel NaV channel inhibitors for pain, epilepsy, and cardiac arrhythmias.
• Analytical Reference Standard: Employed as a certified reference material (CRM) in HPLC, LC-MS, and other analytical methods for quality control and method validation in pharmaceutical and chemical analysis.
• Toxicology & Safety Testing: Used in research to understand the effects of sodium channel activators and to develop countermeasures for alkaloid poisoning.
• Basic Biochemical Research: Utilized in studies of membrane biophysics, action potential generation, and cellular excitability.

Basic Information

Product Name	Veratridine
CAS No.	71-62-5
Molecular Formula	C36H51NO11
Molecular Weight	673.80 g/mol
Synonyms	3-Veratroylveracevine; Veratrine (principal alkaloid); Cevadine isomer; (3β,4α,16β)-4,9-Epoxycevane-3,4,12,14,16,17,20-heptol 3-(3,4-dimethoxybenzoate); Vanilloylveracevine; NSC 215916; Veratridina; Veratridinum
EINECS	200-759-1

Quality Control

Our Veratridine is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications. We support our clients' regulatory needs with full documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability and potency. Keep container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.