Description

6-Maleimidocaproic Acid-Pfp Ester is a heterobifunctional crosslinking reagent featuring a maleimide group and an activated pentafluorophenyl (Pfp) ester. This compound is specifically engineered for the efficient, site-specific conjugation of biomolecules, such as antibodies and peptides, under mild aqueous conditions. It is an essential tool for researchers and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and diagnostic assay production, where precise and stable linkages are critical.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serves as a key intermediate for constructing cleavable or non-cleavable linkers, connecting cytotoxic payloads to monoclonal antibodies.
• Protein and Peptide Labeling: Used to attach fluorescent dyes, biotin, or other reporter molecules to cysteine-containing proteins via the maleimide group.
• Surface Functionalization: Enables the covalent immobilization of biomolecules onto sensor chips, nanoparticles, or solid supports for biosensor and diagnostic device development.
• Polymer Modification: Facilitates the introduction of reactive handles into polymers or hydrogels for creating bioactive materials in tissue engineering and drug delivery.
• Diagnostic Reagent Synthesis: Critical for producing stable conjugates used in ELISA, lateral flow assays, and other immunoassay platforms.

Basic Information

Product Name	6-Maleimidocaproic Acid-Pfp Ester
CAS No.	692739-25-6
Molecular Formula	C17H13F5N2O5
Molecular Weight	420.29 g/mol
Synonyms	6-Maleimidocaproic Acid Pentafluorophenyl Ester; PFP 6-Maleimidocaproate; N-(6-Maleimidocaproyloxy)succinimide Pentafluorophenyl Ester; 6-Maleimidohexanoic Acid PFP Ester; Maleimide-C6-PFP; MC6-PFP; Pentafluorophenyl 6-Maleimidocaproate; SM(PEG)6 PFP Ester (related compound)
EINECS	Contact for details

Quality Control

Our 6-Maleimidocaproic Acid-Pfp Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for sensitive bioconjugation applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and reliability for your research and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.