Description

Tetrakis-(n-Succinimidylcarboxypropyl)Pentaerythritol is a tetravalent, amine-reactive crosslinking reagent based on a pentaerythritol core, designed for the efficient conjugation of biomolecules. Its value lies in providing controlled, multivalent attachment points, significantly enhancing the stability and avidity of bioconjugates compared to monovalent linkers. This compound is essential for researchers and manufacturers in bioconjugation, diagnostic assay development, and advanced drug delivery systems, where creating robust protein-protein or protein-carrier complexes is critical.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: For constructing stable, tetrameric linkages between cytotoxic payloads and monoclonal antibodies.
• Diagnostic Reagent Manufacturing: Crosslinking enzymes (e.g., HRP, ALP) or fluorescent dyes to antibodies and antigens for ELISA and lateral flow assays.
• Polymer-Protein Conjugate Synthesis: Creating multivalent PEGylated proteins or other polymer-biomolecule hybrids to improve pharmacokinetics.
• Surface Functionalization: Immobilizing multiple biomolecules onto chips, beads, or other solid supports for biosensors and microarray platforms.
• Vaccine Development: Conjugating carrier proteins to polysaccharide or peptide antigens to enhance immunogenicity.
• Crosslinking for Structural Studies: Stabilizing protein complexes for analysis via mass spectrometry or microscopy.

Basic Information

Item	Detail
Product Name	Tetrakis-(n-Succinimidylcarboxypropyl)Pentaerythritol
CAS No.	681286-95-3
Molecular Formula	C41H48N4O20
Molecular Weight	916.84 g/mol
Synonyms	Pentaerythritol-based Tetra-NHS Ester; Tetra-SPDP; 4-Arm PEG-NHS Ester (Pentaerythritol core); NSC 4-Arm NHS Ester; Pentaerythritol tetrakis(3-(N-succinimidyloxycarbonyl)propionate); Pentaerythritol PEG4 tetra-NHS ester; Tetravalent NHS-activated crosslinker
EINECS	Contact for details

Quality Control

Our Tetrakis-(n-Succinimidylcarboxypropyl)Pentaerythritol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and solvent residue levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and the active NHS ester groups are susceptible to hydrolysis. For long-term stability, store under inert atmosphere (argon or nitrogen) and allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (Functional NHS ester)
Solvent Residues (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.