Description

7-Deaza-2'-Deoxyxanthosine Cep is a high-purity nucleoside analog building block, specifically a 7-deaza-2'-deoxyxanthosine derivative with a Cep protecting group. This compound is critical for the synthesis of modified oligonucleotides, enabling advanced research in molecular biology and therapeutic development. It is primarily used by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on antisense technology, siRNA, and diagnostic probe development.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA strands.
• Antisense & siRNA Therapeutics: Used to incorporate stable, nuclease-resistant modifications into therapeutic oligonucleotides to enhance target binding and pharmacokinetic profiles.
• Diagnostic Probe Development: Essential for creating high-specificity fluorescent probes and primers for PCR, qPCR, and next-generation sequencing applications.
• Structural Biology Studies: Employed to investigate nucleic acid structure, function, and protein-nucleic acid interactions.
• Medicinal Chemistry: Serves as a scaffold for the development of novel nucleoside-based antiviral and anticancer agents.

Basic Information

Product Name	7-Deaza-2'-Deoxyxanthosine Cep
CAS No.	676456-10-3
Molecular Formula	C17H19N3O5
Molecular Weight	345.35 g/mol
Synonyms	7-Deaza-2'-deoxyxanthosine, 4-cyanobenzyl protected; 7-Deaza-dX Cep; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-[(4-cyanobenzyl)oxy]-7H-pyrrolo[2,3-d]pyrimidin-2(3H)-one; 4-Cyanobenzyl 7-deaza-2'-deoxyxanthosine; Cep-protected 7-deaza-2'-deoxyxanthosine; 7-Deaza-dXan(Cep); Nucleoside building block 676456-10-3
EINECS	Contact for details

Quality Control

Our 7-Deaza-2'-Deoxyxanthosine Cep is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.