Description

O6-[4-(Aminomethyl)Benzyl]Guanine is a high-purity, synthetic small molecule inhibitor primarily used in biochemical and pharmaceutical research. This compound is valued for its specific activity as an O6-alkylguanine-DNA alkyltransferase (AGT) inhibitor, which is critical for targeted cancer therapy studies. It is essential for researchers and developers in the fields of oncology research, molecular biology, and medicinal chemistry, particularly for investigating DNA repair mechanisms and developing novel chemotherapeutic agents.

Application

• Key reagent in biochemical research targeting DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (AGT).
• Used in the development and evaluation of novel chemotherapeutic strategies, especially for sensitizing tumor cells to alkylating agents.
• Critical component in molecular biology studies focused on understanding and overcoming chemotherapy resistance mechanisms.
• Employed in medicinal chemistry for the synthesis and screening of more potent AGT inhibitors.
• Utilized in academic and industrial R&D laboratories for high-throughput screening assays.
• Acts as a reference standard in analytical method development for pharmacokinetic and pharmacodynamic studies.

Basic Information

Item	Detail
Product Name	O6-[4-(Aminomethyl)Benzyl]Guanine
CAS No.	674799-96-3
Molecular Formula	C13H14N6O
Molecular Weight	270.29 g/mol
Synonyms	O6-(4-Aminomethylbenzyl)guanine; O6-4-Aminobenzylguanine; AGT Inhibitor O6-BG; O6-Benzylguanine derivative; PaTrin-2 (research code); O6-(p-Aminomethylbenzyl)guanine; DNA repair inhibitor 674799-96-3; BG derivative
EINECS	Contact for details

Quality Control

Our O6-[4-(Aminomethyl)Benzyl]Guanine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.