Description

Butanoic Acid, 4-[[5-[(Dimethylamino)Carbonyl]-2-Pyridinyl]Dithio]-, 2,5-Dioxo-3-Sulfo-1-Pyrrolidinyl Ester is a specialized heterobifunctional crosslinking reagent designed for advanced bioconjugation and protein modification. This compound matters for its ability to introduce cleavable disulfide linkages and reactive ester groups, enabling precise and reversible attachment of biomolecules. It is primarily needed by researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic assay production who require sophisticated tools for constructing stable yet controllable molecular complexes.

Application

• Bioconjugation Reagent: For crosslinking proteins, peptides, or antibodies with other biomolecules or solid supports via cleavable disulfide bonds.
• Proteomics Research: Used in the synthesis of activity-based probes (ABPs) or affinity tags to study protein function and interactions.
• Drug-Linker Conjugate Synthesis: Serves as a key intermediate in the development of antibody-drug conjugates (ADCs) with controlled-release mechanisms.
• Surface Functionalization: Modification of sensor chips, nanoparticles, or chromatography media for biosensing and separation applications.
• Stable Isotope Labeling: Potential use in creating mass spectrometry tags for quantitative proteomic analysis.
• Polymer Chemistry: As a functional monomer or crosslinker for synthesizing smart polymers with redox-responsive properties.

Basic Information

Product Name	Butanoic Acid, 4-[[5-[(Dimethylamino)Carbonyl]-2-Pyridinyl]Dithio]-, 2,5-Dioxo-3-Sulfo-1-Pyrrolidinyl Ester
CAS No.	663599-07-3
Molecular Formula	C16H18N4O8S3
Molecular Weight	514.53 g/mol
Synonyms	4-((5-((Dimethylamino)carbonyl)pyridin-2-yl)disulfanyl)butanoic acid 2,5-dioxopyrrolidin-1-yl 3-sulfopropanoate; 3-Sulfo-NHS-PyridylSS-Butyrate; Sulfo-NHS-SS-Pyridine; Heterobifunctional Crosslinker (NHS ester/Pyridyl disulfide); 4-[[5-[(Dimethylamino)carbonyl]-2-pyridinyl]dithio]butanoic acid 2,5-dioxo-3-sulfopiperidinyl ester; N-Succinimidyl 3-((2-(5-((dimethylamino)carbonyl)pyridinyl)dithio)propanoate) sulfonate; PyridylSS-Sulfo-NHS-Biotin analog; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our production of this high-purity biochemical reagent adheres to stringent quality protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation via NMR and mass spectrometry. We provide detailed Certificates of Analysis (COA) with every shipment, documenting critical parameters such as assay, identity, and impurity profiles to ensure consistency and reliability for your research and development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.