Description

1-(2-(2-(2-Aminoethoxy)Ethoxy)Ethyl)-1H-Pyrrole-2,5-Dione is a specialized heterocyclic compound featuring a maleimide core linked to a hydrophilic polyether amine chain. This unique bifunctional structure makes it a critical intermediate for creating advanced, site-specific bioconjugates and functionalized polymers. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise, stable linkages for drug delivery systems, diagnostic reagents, and biomaterials. The compound's reactive maleimide group enables selective coupling with thiols, while its amine-terminated spacer enhances solubility and provides a secondary functional handle.

Application

• Bioconjugation Reagent: A key building block for the site-specific conjugation of peptides, proteins, antibodies, and oligonucleotides via thiol-maleimide chemistry.
• ADC (Antibody-Drug Conjugate) Development: Used as a linker-payload component to create stable, cleavable, or non-cleavable linkages between cytotoxic drugs and monoclonal antibodies.
• Polymer Functionalization: Serves as a monomer or crosslinker for synthesizing functionalized hydrogels, smart polymers, and drug-loaded nanoparticles with tailored release profiles.
• Diagnostic Probe Synthesis: Employed to attach fluorescent dyes, chelators, or other reporter molecules to targeting biomolecules for imaging and diagnostic assays.
• Surface Modification: Used to create reactive coatings on biosensor surfaces, chromatography media, and medical devices to enable biomolecule immobilization.
• Research Chemical: A valuable tool in academic and industrial R&D for exploring novel bioconjugation strategies and materials science applications.

Basic Information

Product Name	1-(2-(2-(2-Aminoethoxy)Ethoxy)Ethyl)-1H-Pyrrole-2,5-Dione
CAS No.	660843-23-2
Molecular Formula	C12H18N2O5
Molecular Weight	270.28 g/mol
Synonyms	Maleimide-PEG3-amine; 3-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)-1H-pyrrole-2,5-dione; Amine-PEG3-maleimide; N-(2-(2-(2-Aminoethoxy)ethoxy)ethyl)maleimide; 2,5-Pyrroledione, 1-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-; Mal-PEG3-NH2; PEG3 spacer maleimide; Amino-PEG3-C2-maleimide
EINECS	Contact for details

Quality Control

Our 1-(2-(2-(2-Aminoethoxy)Ethoxy)Ethyl)-1H-Pyrrole-2,5-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for bioconjugation and pharmaceutical research. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container should be sealed under an inert atmosphere after each use and allowed to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.