Description

Mal-Peg2-Amine is a heterobifunctional polyethylene glycol (PEG) linker featuring a maleimide group at one terminus and a primary amine at the other, separated by a short PEG spacer. This compound is a critical reagent for creating stable, site-specific bioconjugates, enabling the cross-linking of thiol-containing biomolecules (like antibodies or peptides) with amine-reactive targets. It is essential for researchers and manufacturers in the fields of biopharmaceutical development, advanced drug delivery systems, and diagnostic assay production who require precise and reproducible conjugation chemistry.

Application

• Antibody-Drug Conjugate (ADC) Development: Site-specific conjugation of cytotoxic drugs to monoclonal antibodies via cysteine residues.
• Protein and Peptide Modification: Introduction of functional handles (e.g., fluorophores, biotin, other drugs) onto thiol-containing proteins.
• PEGylation Reagent: Used to PEGylate thiolated therapeutics to improve pharmacokinetic properties such as solubility and circulation half-life.
• Diagnostic Probe Synthesis: Conjugation of enzymes or fluorescent dyes to antibodies or oligonucleotides for ELISA, flow cytometry, or in vivo imaging applications.
• Surface Functionalization: Immobilization of biomolecules onto amine-reactive sensor chips or nanoparticles for biosensor and nanomedicine platforms.
• Cross-linking Agent: For creating defined protein-protein or protein-polymer conjugates with controlled stoichiometry.

Basic Information

Product Name	Mal-Peg2-Amine
CAS No.	660843-22-1
Molecular Formula	C15H24N2O6
Molecular Weight	328.36 g/mol
Synonyms	Maleimide-PEG2-Amine; 3-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]propyl-1H-pyrrole-2,5-dione; Maleimido-PEG2-NH2; 2,5-Pyrrolidinedione, 3-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]propyl-; Amine-PEG2-Maleimide; MAL-PEG2-NH2; N-(2-Aminoethyl)maleimide-PEG2; Heterobifunctional PEG linker, Maleimide-PEG-Amine
EINECS	Contact for details

Quality Control

Our Mal-Peg2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by titration)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.