Description

o-[2-(Boc-Amino)Ethyl]-O′-(2-Maleimidoethyl)Ethylene Glycol is a specialized heterobifunctional crosslinking reagent designed for advanced bioconjugation and polymer chemistry. Its core value lies in its dual functionality, featuring a maleimide group for thiol-specific coupling and a Boc-protected amine for orthogonal deprotection and further functionalization. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science, where precise and stable linkage of biomolecules or polymers is required.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key intermediate for constructing stable, cleavable linkers connecting cytotoxic payloads to monoclonal antibodies.
• Protein/Peptide Labeling & Immobilization: For site-specific conjugation of fluorescent dyes, enzymes, or other probes to cysteine residues on proteins.
• Surface Functionalization: Modifying gold nanoparticles, biosensor chips, or chromatography resins with amine-reactive groups via the maleimide-thiol chemistry.
• Polymer Modification & Hydrogel Synthesis: Introducing reactive handles into polymer backbones or crosslinking polymer chains to create functional biomaterials.
• Diagnostic Assay Development: Creating stable conjugates for ELISA, lateral flow assays, or other immunoassay formats.
• Prodrug Synthesis: Designing stimuli-responsive prodrug systems where the linker is cleaved under specific biological conditions.

Basic Information

Product Name	o-[2-(Boc-Amino)Ethyl]-O′-(2-Maleimidoethyl)Ethylene Glycol
CAS No.	660843-21-0
Molecular Formula	C18H30N2O7
Molecular Weight	386.44 g/mol
Synonyms	Boc-NH-PEG2-Maleimide; 3-[2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy]ethyl (2-methyl-2-propanyl)carbamate; 1-[2-[2-[2-[[(1,1-Dimethylethoxy)carbonyl]amino]ethoxy]ethoxy]ethyl]-1H-pyrrole-2,5-dione; Boc-Amino-PEG2-Maleimide; Boc-NH-PEG2-MAL; t-Butoxycarbonylamino-PEG2-Maleimide; Boc-PEG2-Maleimide; Heterobifunctional PEG Crosslinker, Boc-amine and Maleimide
EINECS	Contact for details

Quality Control

Our o-[2-(Boc-Amino)Ethyl]-O′-(2-Maleimidoethyl)Ethylene Glycol is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for critical research and development. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.