Description

Methoxy-Peg-Cooh Average M.W. 2000 is a monofunctional, heterobifunctional polyethylene glycol derivative featuring a methoxy group at one terminus and a carboxylic acid group at the other. This specific molecular weight and functionalization make it an exceptionally versatile building block for creating biocompatible conjugates and functionalized surfaces. It is essential for researchers and formulators in the pharmaceutical and biomedical industries who require precise, water-soluble linkers. The compound is widely used to modify peptides, proteins, and nanoparticles to enhance solubility, stability, and pharmacokinetic profiles.

Application

• Bioconjugation and Drug Delivery: A key linker for PEGylating therapeutic peptides, proteins, and oligonucleotides to reduce immunogenicity and prolong circulation half-life.
• Surface Functionalization: Used to create hydrophilic, non-fouling coatings on nanoparticles, medical devices, and diagnostic sensors.
• Polymer Chemistry: Serves as a macroinitiator or macromonomer for synthesizing amphiphilic block copolymers and hydrogels.
• Diagnostic Reagents: Employed to conjugate targeting ligands (e.g., antibodies, peptides) to fluorescent dyes or contrast agents for imaging applications.
• Material Science: Facilitates the development of smart materials and responsive surfaces due to its tunable properties and reactive end-group.

Basic Information

Product Name	Methoxy-Peg-Cooh Average M.W. 2000
CAS No.	656820-38-1
Molecular Formula	CnH2n+2On+2 (n~45) / Typically represented as CH3O-(CH2CH2O)n-CH2COOH
Molecular Weight	Average 2000 Da
Synonyms	mPEG-COOH 2000; mPEG-Carboxylic Acid 2000; Methoxy Polyethylene Glycol Carboxylic Acid (MW 2000); α-Methoxy-ω-carboxy PEG; O-(2-Carboxyethyl)-O'-methylpolyethylene glycol 2000; PEG Methyl Ether Carboxylic Acid; mPEG Acid; 2-[2-(2-Methoxyethoxy)ethoxy]acetic acid (oligomer); Poly(ethylene glycol) methyl ether carboxylic acid
EINECS	Contact for details

Quality Control

Our Methoxy-Peg-Cooh 2000 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, precise molecular weight distribution, and functional group integrity. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as assay, polydispersity index (PDI), and acid value. Our quality commitment supports applications in GMP environments and research requiring reproducible and reliable performance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) and at temperatures between 2°C and 8°C for long-term stability. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Average Molecular Weight (GPC)	1900 - 2100 Da
Polydispersity Index (PDI)	≤ 1.05
Assay (Acid Value Titration)	≥ 95%
Methoxy Substitution (NMR)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.