Description

Mpeg3-Nhs CAS NO 622405-78-1 is a heterobifunctional polyethylene glycol (PEG) derivative featuring an NHS ester at one terminus and a methoxy group at the other. This compound is a critical reagent for creating stable, hydrophilic, and biocompatible conjugates in aqueous environments. It is primarily utilized by researchers and manufacturers in the pharmaceutical and bioconjugation sectors for the development of advanced drug delivery systems, diagnostic agents, and modified biomolecules.

Application

• Bioconjugation and PEGylation: Covalent attachment of peptides, proteins, and antibodies to introduce stealth properties, improve solubility, and extend circulatory half-life.
• Drug Delivery System Development: Synthesis of prodrugs and linker systems for targeted and controlled-release therapeutic formulations.
• Diagnostic Reagent Preparation: Labeling of biomarkers, enzymes, and other detection molecules for use in immunoassays and biosensors.
• Surface Functionalization: Modification of nanoparticles, quantum dots, and solid supports to create hydrophilic, non-fouling surfaces for biomedical applications.
• Crosslinking Agent: Used as a water-soluble crosslinker for amine-containing polymers or biomaterials under mild conditions.
• Intermediate for Further Synthesis: Serves as a key building block for creating more complex multi-arm or functionalized PEG derivatives.

Basic Information

Product Name	Mpeg3-Nhs
CAS No.	622405-78-1
Molecular Formula	C17H29NO9
Molecular Weight	391.42 g/mol
Synonyms	mPEG3-NHS Ester; Methoxy-PEG3-NHS Ester; α-Methoxy-ω-(N-succinimidyloxycarbonyl) triethylene glycol; NHS-PEG3-OMe; 2,5-Dioxopyrrolidin-1-yl 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]acetate; 1-[2-[2-(2-Methoxyethoxy)ethoxy]acetyloxy]-2,5-pyrrolidinedione; O-(N-Succinimidyl)-O'-methyl-triethylene glycol
EINECS	Contact for details

Quality Control

Our Mpeg3-Nhs is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive bioconjugation work. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under a desiccated (anhydrous) atmosphere. This product is hygroscopic (moisture-sensitive) and the NHS ester group is susceptible to hydrolysis. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Freely soluble in DMF, DMSO, acetonitrile; soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.