Description

Biotin-Peg11-Amine CAS NO 604786-74-5 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a biotin group at one terminus and a primary amine at the other. This compound is essential for creating stable, site-specific conjugations in advanced bioconjugation and drug delivery systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic industries for applications such as antibody-drug conjugate (ADC) development, surface functionalization, and the creation of affinity matrices.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a critical spacer and functional handle for attaching cytotoxic payloads to monoclonal antibodies, enhancing solubility and pharmacokinetics.
• Surface Functionalization: Used to biotinylate nanoparticles, quantum dots, or sensor surfaces for subsequent capture with streptavidin, enabling precise assembly of diagnostic and research platforms.
• Affinity Chromatography Reagent: A key intermediate for synthesizing biotinylated ligands or immobilizing biomolecules onto streptavidin/avidin resins for purification.
• Proteomics & Biomolecule Labeling: Facilitates the biotinylation of peptides, proteins, or oligonucleotides via its amine-reactive end for pull-down assays, imaging, and detection.
• Drug Delivery System Component: Incorporated into polymer-drug conjugates or liposomal formulations to enable targeted delivery through biotin-receptor interactions.
• Cross-linking Agent: Acts as a heterobifunctional crosslinker for coupling amine-containing molecules to avidin/biotin-based systems.

Basic Information

Product Name	Biotin-Peg11-Amine
CAS No.	604786-74-5
Molecular Formula	C46H88N4O15S
Molecular Weight	977.28 g/mol
Synonyms	Biotin-PEG11-NH2; Biotin-PEG11-Amine; Biotinylated PEG11 Amine; 5-[(3aS,4S,6aR)-2-Oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-Aminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethyl)pentanamide; Biotin-PEG 11 Amine; Biotin-Polyethylene glycol-amine (n=11); Biotin-PEG11 Alkyl Amine
EINECS	Contact for details

Quality Control

Our Biotin-Peg11-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical research and cGMP-grade manufacturing applications. Certificates of Analysis (COA) with detailed specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Amine)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.