Description

Doxycycline Hcl Hydrate is a semi-synthetic, broad-spectrum tetracycline antibiotic. It is valued for its high bioavailability and effectiveness against a wide range of Gram-positive and Gram-negative bacteria, as well as atypical pathogens. This compound is a critical active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers for the production of oral dosage forms, such as tablets and capsules, used to treat various bacterial infections.

Application

• Pharmaceutical API: Primary raw material for formulating oral antibiotic medications (tablets, capsules, suspensions).
• Veterinary Medicine: Used in the production of treatments for bacterial infections in livestock, poultry, and companion animals.
• Research & Development: Serves as a reference standard and key reagent in microbiological and pharmacological research studies.
• Treatment of Specific Infections: Formulated for conditions including respiratory tract infections, Lyme disease, acne, and sexually transmitted diseases.
• Malaria Prophylaxis: Used in combination therapies for the prevention of malaria in specific regions.

Basic Information

Product Name	Doxycycline Hcl Hydrate
CAS No.	69935-17-7
Molecular Formula	C₂₂H₂₄N₂O₈ • HCl • ½H₂O
Molecular Weight	512.94 g/mol (for monohydrate)
Synonyms	Doxycycline Hydrochloride Hemihydrate; Doxycycline HCl; Doxycycline Monohydrate Hydrochloride; 4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride, compound with water (1:0.5); Vibramycin; GS 3065; Doxycycline Hydrochloride Hydrate
EINECS	Contact for details

Quality Control

Our Doxycycline Hcl Hydrate is manufactured under strict quality management systems. It is tested to meet relevant pharmacopeial standards such as USP, EP, and BP. Every batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles to ensure it meets your specific application requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in its original packaging to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	Yellow to yellow-orange crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC, anhydrous basis)	95.0% - 102.0%
Water Content (KF)	1.5% - 3.5%
pH (1% solution)	2.0 - 3.0
Specific Rotation	-105° to -120°
Heavy Metals	≤ 20 ppm
Residual Solvents	Conforms to ICH Q3C
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.