Description

trans-4-(Maleimidomethyl)Cyclohexanecarboxylic Acid is a high-purity bifunctional linker molecule containing both a carboxylic acid and a maleimide group. This compound is critical for creating stable, site-specific conjugations between biomolecules and various surfaces or carriers via its orthogonal reactive handles. It is primarily needed by researchers and manufacturers in the bioconjugation, pharmaceutical development, and advanced materials sectors for producing antibody-drug conjugates (ADCs), peptide modifications, and functionalized polymers.

Application

• Bioconjugation Reagent: A key building block for the site-specific modification of proteins, antibodies, and peptides via the maleimide-thiol coupling reaction.
• Antibody-Drug Conjugate (ADC) Linker: Used in the synthesis of linker-payload constructs for targeted cancer therapies, connecting cytotoxic drugs to monoclonal antibodies.
• Surface Functionalization: Employed to introduce reactive maleimide groups onto nanoparticles, biosensors, chromatographic resins, and other solid supports for subsequent biomolecule immobilization.
• Cross-linking Agent: Facilitates the formation of stable covalent bonds between molecules containing thiol and amine groups (after activation of the carboxylic acid).
• Polymer Chemistry: Serves as a monomer or modifier for synthesizing functional polymers with pendant reactive sites for further chemical grafting.
• Diagnostic Reagent Synthesis: Used in the development of fluorescent probes, enzyme labels, and other diagnostic tools requiring stable covalent attachment.

Basic Information

Product Name	trans-4-(Maleimidomethyl)Cyclohexanecarboxylic Acid
CAS No.	69907-67-1
Molecular Formula	C12H15NO4
Molecular Weight	237.25 g/mol
Synonyms	4-(Maleimidomethyl)cyclohexanecarboxylic Acid (trans isomer); (1r,4r)-4-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-ylmethyl)cyclohexanecarboxylic Acid; trans-4-(Maleimidomethyl)-1-cyclohexanecarboxylic Acid; 4-(Maleimidomethyl)cyclohexane-1-carboxylic Acid; MCC Acid; Maleimidomethyl Cyclohexane Carboxylic Acid; 1H-Pyrrole-2,5-dione, 1-[(1r,4r)-4-(carboxymethyl)cyclohexyl]methyl]-; trans-4-MCC Acid
EINECS	Contact for details

Quality Control

Our trans-4-(Maleimidomethyl)Cyclohexanecarboxylic Acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.