Description

α-Fluoromethylhistamine is a fluorinated derivative of histamine, a key biogenic amine involved in numerous physiological processes. This compound is of significant interest in advanced pharmaceutical research and development, particularly as a potent and selective histamine H3 receptor antagonist. It serves as a critical building block and reference standard for neuroscientists and medicinal chemists targeting central nervous system disorders, metabolic regulation, and inflammatory pathways. Its unique structure makes it a valuable tool for probing receptor-ligand interactions and developing novel therapeutic agents.

Application

• Pharmaceutical R&D Intermediate: A key synthetic precursor for developing novel histamine H3 receptor antagonists and inverse agonists.
• Neuroscience Research: Used as a reference standard and pharmacological tool in studies of sleep-wake cycles, cognitive function, and appetite regulation.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and binding assays to characterize new drug candidates targeting the histaminergic system.
• Metabolic Disorder Research: Investigated for its potential role in modulating energy homeostasis and lipid metabolism.
• Labeled Compound Synthesis: Serves as a starting point for synthesizing radiolabeled (e.g., tritiated) or fluorescent-tagged analogs for tracer studies.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in pharmacology and medicinal chemistry.

Basic Information

Product Name	α-Fluoromethylhistamine
CAS No.	69672-40-8
Molecular Formula	C7H10FN3
Molecular Weight	155.17 g/mol
Synonyms	α-Fluoromethylhistamine; (S)-α-Fluoromethylhistamine; 2-(1H-Imidazol-4-yl)ethyl(fluoromethyl)amine; Fluoromethylhistamine; H3 receptor antagonist precursor; Fmh
EINECS	Contact for details

Quality Control

Our α-Fluoromethylhistamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment, detailing all specified parameters to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.