Description

Glycyl-Proline-1-Naphthylamide is a specialized chromogenic peptide substrate used in enzymatic assays. This compound is critical for the detection and quantification of specific protease activities, particularly dipeptidyl peptidase IV (DPP-IV). It is an essential reagent for researchers and quality control laboratories in the pharmaceutical, diagnostic, and life science sectors requiring precise biochemical analysis.

Application

• Enzymatic Substrate for DPP-IV Assays: Primary chromogenic substrate for the spectrophotometric determination of dipeptidyl peptidase IV (DPP-IV/CD26) activity in research and diagnostic kits.
• Biochemical Research: Used in enzyme kinetics studies, inhibitor screening, and characterization of protease function in metabolic and immunological pathways.
• Pharmaceutical Development: Employed in high-throughput screening (HTS) platforms to identify and validate novel DPP-IV inhibitors for therapeutic applications, such as in type 2 diabetes drug discovery.
• Diagnostic Reagent Manufacturing: A key component in the formulation of clinical diagnostic reagents for measuring DPP-IV activity in serum or plasma samples.
• Cell Biology & Immunology: Used to study the role of DPP-IV in T-cell activation, cancer biology, and other cellular processes where surface protease activity is a marker.
• Quality Control Testing: Serves as a reference standard or critical reagent in QC labs for validating the performance of enzymatic assays and diagnostic equipment.

Basic Information

Product Name	Glycyl-Proline-1-Naphthylamide
CAS No.	69519-57-9
Molecular Formula	C₁₉H₂₂N₄O₃
Molecular Weight	354.41 g/mol
Synonyms	Gly-Pro-1-NA; GP-1-NA; H-Gly-Pro-1-naphthylamide; Glycylproline 1-Naphthylamide; Gly-Pro-βNA; DPP-IV Substrate; 1-Naphthylamide Glycyl-L-proline; L-Glycyl-L-proline 1-naphthylamide; Dipeptidyl Peptidase IV Substrate
EINECS	Contact for details

Quality Control

Our Glycyl-Proline-1-Naphthylamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for sensitive biochemical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reproducible performance and batch-to-batch consistency for your critical research and diagnostic workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Solubility	Clear, colorless solution in DMSO or DMF
Biological Activity	Suitable for DPP-IV enzyme assays

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.